Song, Ruichong; Tago, Tetsuro; Tatsuta, Maho; Shiraishi, Nana; Iwai, Kumiko; Hirano, Keiichi; Toyohara, Jun; Tanaka, Hiroshi published their research in ChemistrySelect in 2021. The article was titled ãN-Alkyl 3-aminobut-2-enenitrile as a Non-radioactive Side Product in Nucleophilic 18F-Fluorinationã?Computed Properties of C5H3Br2N The article contains the following contents:
Acetonitrile acted as a reactant under the conventional reaction conditions for aliphatic nucleophilic 18F-fluorination in acetonitrile to provide the N-alkyl 3-aminobut-2-enenitrile (E)-I as one of the side products was found. Dimerization of acetonitrile promoted by a complex of K2CO3 and K222 provided 3-aminobut-2-enenitrile, which acted as nucleophile to provide N-alkyl amino derivatives (E)-I. Based on the finding, avoiding acetonitrile in the drying of [18F]fluoride as well as 18F-labeling enabled the preparation of 18F-labeled compounds II (X = 18F) containing only a small amount of the corresponding alc. II (X = OH). Finally, usage of an automated synthesizer to achieve an efficient phase-tag-assisted synthesis of 18F-labeled stilbene derivative as a 18F-labeled amyloid-β ligand (X = 18F) is described. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)
2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C5H3Br2N