Application of 100-48-1In 2021 ,ãElectroreductive C3 Pyridylation of Quinoxalin-2(1H)-ones: An Effective Way to Access Bidentate Nitrogen Ligandsã?appeared in Organic Letters. The author of the article were Wen, Jiangwei; Yang, Xiaoting; Yan, Kelu; Qin, Hongyun; Ma, Jing; Sun, Xuejun; Yang, Jianjing; Wang, Hua. The article conveys some information:
A simple and practical electroreductive-induced C3 pyridylation of quinoxalin-2(1H)-ones with readily available cyanopyridines was reported. More than 36 examples were supplied, and the reaction performed in >95% yield. The present protocol provided a convenient, efficient and gram-scale synthesis strategy for a series of new types of potential bidentate nitrogen ligands I [R = H, Me, F, etc.; R1 = H, Me, Cl; R2 = H, Me, Ph, etc.; R3 = H, Me; R4 = 4-pyridyl, 2-chloro-4-pyridyl, 1-isoquinolyl, etc.; RR1 = CH=CH-CH=CH]. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application of 100-48-1