Reference of 2-Bromo-5-methylpyridineIn 2019 ,ãSystematic investigation of hydrogen-bond propensities for informing co-crystal design and assemblyã?appeared in CrystEngComm. The author of the article were Sarkar, Nandini; Sinha, Abhijeet S.; Aakeroy, Christer B.. The article conveys some information:
Co-crystallizations can be utilized for generating new solid forms of a target substance in order to alter or enhance some specific bulk phys. property. Generally, selection of the co-former (the necessary partner for the target mol.) is based on existing structural information about mol. recognition events involving complementary functional groups, and extensive exptl. screening methods. In this study, we utilize structure-informatics in an attempt to predict if two different mols. will form a co-crystal or not. Our study is based on hydrogen-bond propensity (HBP), and the key premise of our approach rests on whether target-co-former interactions are more likely to take place than either target-target or co-former-co-former hydrogen bonds. We examined six different target mols. in combination with 25 possible co-formers each and used the HBP protocol for predicting if a co-crystal would form or not. The predictions were then compared with results from an exptl. co-crystal screen of the 150 different combinations. The correct outcome was successfully predicted 92-95% of the time which shows that for this series of small mols., HBP is a very reliable indicator for determining if a co-crystal will form between a target mol. and a particular co-former. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5Reference of 2-Bromo-5-methylpyridine)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 2-Bromo-5-methylpyridine