Yao, Xing-Qi; Tong, Wen-Yan; Wang, Kang; Qu, Shuanglin; Wang, Jianbo published their research in Organometallics in 2021. The article was titled ãAzacycle-Directed Formal Aromatic C(sp2)-H Insertion with Cr(0) Fischer Carbene Complex via Oxidative Hydrogen Migrationã?HPLC of Formula: 3510-66-5 The article contains the following contents:
An azacycle-directed intermol. aromatic C(sp2)-H functionalization of Cr(0) Fischer carbene complexes under catalyst-free conditions is reported. Arenes with pyridines, pyrimidine, and pyrazole as directing groups reacted with chromium(0) carbene complexes in good yields and excellent regioselectivities. According to the mechanistic studies based on experiments and computations with d. functional theory (DFT), the reaction is proposed to follow an unconventional mechanism via oxidative hydrogen migration and reductive elimination, which is different from the classical electrophilic substitution mechanism.2-Bromo-5-methylpyridine(cas: 3510-66-5HPLC of Formula: 3510-66-5) was used in this study.
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 3510-66-5