In 2020,RSC Advances included an article by Recio, Javier; Filace, Fabiana; Gala, Elena; Perez-Redondo, Adrian; Alvarez-Builla, Julio; Burgos, Carolina. Reference of 2-Bromopyridin-3-amine. The article was titled 《Studies on the preparation of aminobipyridines and bipyridine sultams via an intramolecular free radical pathway》. The information in the text is summarized as follows:
A variety of aminated bipyridines and bipyridine sultams are prepared by intramol. radical [1,5]-ipso and [1,6]-ortho substitutions, using a sulfonamide as a linker to connect the pyridyl radical to the pyridine under attack. For the cases studied, different regiochemistries were observed depending on the initial position of the sulfonamide linker. In the experiment, the researchers used 2-Bromopyridin-3-amine(cas: 39856-58-1Reference of 2-Bromopyridin-3-amine)
2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Reference of 2-Bromopyridin-3-amine