Quality Control of 2-Bromopyridin-3-amineOn November 5, 2021 ,《Selective Thiocyanation and Aromatic Amination To Achieve Organized Annulation of Enaminone with Thiocyanate》 appeared in Organic Letters. The author of the article were Zhang, Jun; She, Mengyao; Liu, Lang; Feng, Xukai; Li, Yao; Liu, Hua; Zheng, Tingting; Leng, Xin; Liu, Ping; Zhang, Shengyong; Li, Jianli. The article conveys some information:
A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields. The experimental part of the paper was very detailed, including the reaction process of 2-Bromopyridin-3-amine(cas: 39856-58-1Quality Control of 2-Bromopyridin-3-amine)
2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Quality Control of 2-Bromopyridin-3-amine