Related Products of 153034-82-3 ,Some common heterocyclic compound, 153034-82-3, molecular formula is C6H3FINO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a dry 15mL ChemGlass pressure bottle under N2 was added 4-iodo-2- fluoro-3-formylpyridine (314 mg, 1.25 mmol), (2-chloro-4-fluorophenyl)hydrazine (210 mg, 1.31 mmol), and anhydrous NMP (5 mL). The reaction mixture was purged with argon, heated at 185C for 2h, and then at 140C for 36h. The reaction mixture was worked up according to the procedure described in Intermediate 69A and the crude product was purified by Biotage Silica gel chromatography using a 80g Thompson Single Step silica cartridge with a linear gradient from 100% hexanes to 100% CH2CI2 over 12 column volumes to give 63.5 mg (13.6%) of the title compound as a pale yellow solid, LC/MS (Condition B): ret. T = 3.7 min, (M+H)+ 373.88, 375.88 and 149.3mg (30.3%) of the hydrazone intermediate as a pale yellow solid, LC/MS (Condition B): ret. T = 4.2min, (M+H)+ 393.90, 395.90.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,153034-82-3, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; VELAPARTHI, Upender; FRENNESSON, David B.; SAULNIER, Mark G.; AUSTIN, Joel F.; HUANG, Audris; BALOG, James Aaron; VYAS, Dolatrai M.; WO2012/9510; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem