Sun, Deli; Ma, Guobin; Zhao, Xinluo; Lei, Chuanhu; Gong, Hegui published their research in Chemical Science in 2021. The article was titled 《Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides》.Formula: C5H3BrClN The article contains the following contents:
An asym. Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones I [R1 = Me, Ph, 2-thienyl, etc.; R2 = Me, n-Bu, Bn, etc.; Ar = 4-MeOOCC6H4, 2-methoxy-pyridin-5-yl, 2-naphthyl, etc.] was reported. The reaction tolerated a variety of functional groups under mild reaction conditions, which complements current methods. The utility of this work was demonstrated by facile late-stage functionalization of com. drugs.5-Bromo-2-chloropyridine(cas: 53939-30-3Formula: C5H3BrClN) was used in this study.
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Formula: C5H3BrClN