Adding a certain compound to certain chemical reactions, such as: 60290-21-3, 4-Chloro-1H-pyrrolo[3,2-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 60290-21-3, blongs to pyridine-derivatives compound. Recommanded Product: 4-Chloro-1H-pyrrolo[3,2-c]pyridine
Cul (110 mg, 0.12 mmol), /rans-N, N?-dimethylcyclo hexane- 1, 2-diamine (37.9 iiL, 0.24 mmol) and K2C03 (332 mg, 2.40 mmol) were added to a stirred solution of 4- chloro-lH-pyrrolo[3,2-c]pyridine [60290-21-3] (238 mg, 1.56 mmol) and 4-iodo-l- methyl-lH-imidazole [71759-87-0] (250 mg, 1.20 mmol) in toluene (5 mL). The reaction mixture was stirred at 105 C for 24 h, cooled to room temperature and partitioned between NaHCCL (sat., aq.) and EtOAc. The aqueous phase was extracted with EtOAc (twice). The combined organic phases were washed with brine, dried (MgS04), filtered and the solvents were evaporated in vacuo. The crude mixture was purified by flash column chromatography (silica, heptane/EtOAc, gradient from 100:0 to 0:100) to afford 1-139 (120 mg, 43%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60290-21-3, its application will become more common.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; TRESADERN, Gary John; MARTINEZ LAMENCA, Carolina; LEENAERTS, Joseph Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (171 pag.)WO2019/243535; (2019); A1;,
Pyridine – Wikipedia,
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