In 2022,Fischer, Christian; Veprek, Nynke A.; Peitsinis, Zisis; Ruhmann, Klaus-Peter; Yang, Chao; Spradlin, Jessica N.; Dovala, Dustin; Nomura, Daniel K.; Zhang, Yingkai; Trauner, Dirk published an article in Synlett. The title of the article was 《De novo Design of SARS-CoV-2 Main Protease Inhibitors》.Related Products of 2510-22-7 The author mentioned the following in the article:
The COVID-19 pandemic prompted many scientists to investigate remedies against SARS-CoV-2 and related viruses that are likely to appear in the future. As the main protease of the virus, M Pro, is highly conserved among coronaviruses, it has emerged as a prime target for developing inhibitors. Using a combination of virtual screening and mol. modeling, we identified small mols. that were easily accessible and could be quickly diversified. Biochem. assays confirmed a class of pyridones as low micromolar noncovalent inhibitors of the viral main protease. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 2510-22-7