《A novel, robust method for quantification of multiple kynurenine pathway metabolites in the cerebrospinal fluid》 was written by Schwieler, Lilly; Trepci, Ada; Krzyzanowski, Stanislaw; Hermansson, Sigurd; Granqvist, Mathias; Piehl, Fredrik; Venckunas, Tomas; Brazaitis, Marius; Kamandulis, Sigitas; Lindqvist, Daniel; Jones, Arthur Daniel; Erhardt, Sophie; Brundin, Lena. COA of Formula: C6H5NO2 And the article was included in Bioanalysis in 2020. The article conveys some information:
Kynurenine metabolites are potential modulators of psychiatric disease. We aimed to develop a highly sensitive biochem. anal. of cerebrospinal fluid (CSF) tryptophan (TRP) metabolites, to investigate the stability of metabolites and to confirm our previous findings of aberrant CSF quinolinic acid (QUIN) and picolinic acid (PIC) in suicide attempters using this method. Ten CSF TRP metabolites were analyzed with ultraperformance LC-MS/MS. The method showed small intra- and interassay variation. Metabolites were stable following freeze-thaw cycles. A decreased CSF PIC/QUIN ratio was found in suicide attempters. The feasibility of reliably determining CSF TRP metabolites were demonstrated, including separation of the two isomers PIC and nicotinic acid (NA) and the finding of a reduced PIC/QUIN ratio replicated in suicide attempters. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6COA of Formula: C6H5NO2)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.COA of Formula: C6H5NO2