《Continuous Flow as Enabling Technology: Synthesis of Heteroaromatic Sulfinates as Bench Stable Cross-Coupling Partners》 was written by Lima, Fabio; Andre, Jerome; Marziale, Alexander; Greb, Andreas; Glowienke, Susanne; Meisenbach, Mark; Schenkel, Berthold; Martin, Benjamin; Sedelmeier, Joerg. Quality Control of 2,6-Dibromopyridine And the article was included in Organic Letters in 2020. The article conveys some information:
An enabling continuous flow setup for handling of unstable organolithium intermediates and synthesis of heteroaryl sulfinates on a multigram scale is described. The developed continuous flow process allows for the synthesis and simple isolation of heteroaryl sulfinates which are otherwise challenging to access in classical batch mode. The lithium sulfinate salts prepared by this method were shown to be efficient reaction partners in palladium catalyzed C(sp2)-C(sp2) cross-coupling to access medicinally relevant bis-heteroaryl motifs. In addition to this study using 2,6-Dibromopyridine, there are many other studies that have used 2,6-Dibromopyridine(cas: 626-05-1Quality Control of 2,6-Dibromopyridine) was used in this study.
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Quality Control of 2,6-Dibromopyridine