In 2017,Gao, Jie; Bhunia, Subhajit; Wang, Kailiang; Gan, Lu; Xia, Shanghua; Ma, Dawei published 《Discovery of N-(Naphthalen-1-yl)-N’-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers》.Organic Letters published the findings.Product Details of 13534-97-9 The information in the text is summarized as follows:
In the presence of Cu2O and the oxalamide I, aryl- and heteroaryl bromides and iodides were aminated chemoselectively with primary amines (alkyl favored over aryl), ammonium hydroxide, and secondary cyclic amines and N-methylbenzylamine using KOH in EtOH at 50-80° to yield aryl- and heteroarylamines such as N-benzyl-p-anisidine in 35-98% yields using 0.1-0.5 mol% of Cu2O. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Product Details of 13534-97-9