In 2019,Chemical Science included an article by Cao, Jia; Wang, Guoqiang; Gao, Liuzhou; Chen, Hui; Liu, Xueting; Cheng, Xu; Li, Shuhua. Application In Synthesis of 4-Cyanopyridine. The article was titled 《Perfluoroalkylative pyridylation of alkenes via 4-cyanopyridine-boryl radicals》. The information in the text is summarized as follows:
A metal-free and photo-free method for the perfluoroalkylative pyridylation of alkenes R1R2C=CH2 [R1 = 4-MeC6H4, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.; R2 = H, Me, Et, Pr; R1R2 = -(CH2)5-] has been developed via a combination of computational and exptl. studies. D. functional theory calculations and control experiments indicate that the homolysis of R3X [R3 = CF3, CF2CF2Cl, CF(CF3)2, etc.; X = Br, I] bonds by the 4-cyanopyridine-boryl radicals in situ generated from 4-cyanopyridine and B2pin2 is the key step. Sequential addition of R3 radicals to alkenes and the selective cross-coupling of the resulting alkyl radicals and 4-cyanopyridine-boryl radicals gives alkene difunctionalization products I with a quaternary carbon center. This method exhibits a broad substrate scope and good functional group compatibility. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application In Synthesis of 4-Cyanopyridine