In 2019,Tetrahedron included an article by Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji. Computed Properties of C6H4N2. The article was titled 《NNN pincer Ru(II)-catalyzed dehydrogenative coupling of 2-aminoarylmethanols with nitriles for the construction of quinazolines》. The information in the text is summarized as follows:
An efficient NNN pincer Ru(II)-catalyzed preparation of quinazolines via acceptorless dehydrogenative strategy was developed. Under the optimized conditions, a broad range of substituted o-aminobenzyl alcs. and (hetero)aryl or alkyl nitriles were well tolerated to afford various 2-substituted quinazolines in high yields. Subsequently, a set of control experiments was performed to elucidate the reaction mechanism, which underwent alc. oxidation, nitrile hydration and cyclocondensation steps. This protocol was featured with several advantages, such as environmental benignity, operational simplicity, broad substrate scope (compatible with aliphatic nitriles, up to 87% yield) and short reaction time (mostly in 2 h). The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C6H4N2