In 2022,Liu, Wenbo; Tao, Ouyang; Chen, Li; Ling, Yun; Zeng, Ming; Jin, Hongguang; Jiang, Dengzhao published an article in RSC Advances. The title of the article was 《Synthesis and characterization of a Cu(II) coordination-containing TAM radical as a nitroxyl probe》.Related Products of 1539-42-0 The author mentioned the following in the article:
Nitroxyl (HNO) has been identified as an important signaling mol. in biol. systems, and it plays critical roles in many physiol. processes. However, its detection remains challenging because of the limited sensitivity and/or specificity of existing detection methods. Low-frequency ESR (EPR) spectroscopy and imaging, coupled with the use of exogenous paramagnetic probes, have been indispensable techniques for the in vivo measurement of various physiol. parameters owing to their specificity, noninvasiveness and good depth of magnetic field penetration in animal tissues. However, the in vivo detection of HNO levels by EPR spectroscopy and imaging is limited due to the need for improved probes. We report the first “”turn on-response”” EPR probe for HNO utilizing a Cu(II) coordination-containing TAM radical (denoted as CuII[TD1]). Upon reaction with HNO, CuII[TD1] shows a 16.1-fold turn-on in EPR signal with a low detection limit of 1.95 μM. Moreover, low-temperature EPR spectroscopic and ESI-MS studies showed that the sensing mechanism relies on the reduction of Cu(II) by HNO. Lastly, CuII[TD1] is selective for HNO over other reactive nitrogen and oxygen species except for some reductants (Cys and Asc). This new Cu(II) coordination-containing TAM radical shows great potential for in vivo EPR HNO applications in the absence of reducing agents and provides insights into developing improved and targeted EPR HNO probes for biomedical applications. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0) was used in this study.
Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0