The author of 《Heterogeneous Copper(I)-Catalyzed Cascade Addition-Oxidative Cyclization of Nitriles with 2-Aminopyridines or Amidines: Efficient and Practical Synthesis of 1,2,4-Triazoles》 were Xia, Jianhui; Huang, Xue; Cai, Mingzhong. And the article was published in Synthesis in 2019. Recommanded Product: 4-Cyanopyridine The author mentioned the following in the article:
The heterogeneous cascade addition-oxidative cyclization of nitriles with 2-aminopyridines or amidines was achieved in 1,2-dichlorobenzene or DMSO at 120-130 °C by using a 1,10-phenanthroline-functionalized MCM-41-supported copper(I) complex [Phen-MCM-41-CuBr] as the catalyst and air as the oxidant. The approach was used to generate a wide variety of 1,2,4-triazole derivatives, e.g., I and II, in mostly high yields. This heterogeneous copper(I) catalyst could be easily prepared in a two-step procedure from com. or readily available and inexpensive reagents and it exhibited higher catalytic activity than the CuBr/1,10-Phen system. Phen-MCM-41-CuBr was also easy to recover and was recyclable up to eight times with almost consistent activity. The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1Recommanded Product: 4-Cyanopyridine)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 4-Cyanopyridine