Application of 53939-30-3In 2019 ,《Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines》 appeared in ACS Omega. The author of the article were Sun, Chao; Yao, Wubing; Chen, Xu; Zhao, Yiwen; Wei, Qiqi; Chen, Zishuang; Wu, Jiashou; Hao, Feiyue; Xie, Huiping. The article conveys some information:
An environmental, highly efficient, and base-promoted selective amination of various polyhalogenated pyridines including the challenging pyridine chlorides, to 2- aminopyridine derivatives I (X = 5-Br, 3-Br, 4-Cl, etc.; R = H, Me; R1 = Me, n-Bu, n-hexyl, Bn, etc.) using water as solvent has been developed. Featuring the use of the new method, the reaction is extended to the transformation on a large scale. Mechanistic studies indicate that the pathway involving a base aidant dissociation of N,N-dimethylformamide to generate the dimethylamine is likely. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Application of 53939-30-3)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 53939-30-3