Pyridoxal phosphate, pyridoxamine phosphate, and folic acid based on ceRNA regulatory network as potential biomarkers for the diagnosis of pulmonary tuberculosis was written by Li, Zhi-Bin;Shi, Li-Ying;Han, Yu-Shuai;Chen, Jing;Zhang, Shan-Qiang;Chen, Jia-Xi;Liu, Jun;Tu, Hui-Hui;Lu, Qi-Qi;Yu, Yi;Jiang, Ting-Ting;Li, Ji-Cheng. And the article was included in Infection, Genetics and Evolution in 2022.Reference of 54-47-7 The following contents are mentioned in the article:
Pulmonary tuberculosis (TB) is a serious disease burden worldwide, and its effective early diagnosis is still facing challenges. Knowledge, acquired from multi-omics integration anal. about the association between different types of differentially expressed mols. in the plasma of TB patients and the disease traits, is anticipated to improve the accuracy of TB diagnosis through the ′′integrative pattern′′. In this study, the lncRNA-miRNA-mRNA interaction network was constructed based on the competing endogenous RNA (ceRNA) hypothesis by integrating our previous data sets of lncRNA, mRNA, miRNA, and metabolites. Moreover, the key regulatory axis was established by co-expression anal. and verified at the level of metabolites. A ceRNA regulatory network consisting of 23 lncRNAs, 10 miRNAs, and 113 mRNAs was constructed. The anal. results suggested that lncRNA (OSBPL10-AS1), miRNA (has-miR-485-5p), and mRNA (SLC23A2) might be involved in the regulation of vitamin metabolism in patients with TB. Metabolite anal. showed that compared with the normal control group, TB patients had abnormal vitamin metabolism, and the expression levels of pyridoxal phosphate, pyridoxamine phosphate, and folic acid were significantly different between the two groups (p < 0.05). Integrated multi-omics anal. showed that vitamin metabolism disorder may be one of the pathol. characteristic of TB. OSBPL10-AS1, hsa-miR-485-5p, SLC23A2, pyridoxal phosphate, pyridoxamine phosphate, and folic acid may collectively constitute the ′′integrative pattern′′ of multiple biomarkers, which may provide an accurate diagnosis of TB. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Reference of 54-47-7).
(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Reference of 54-47-7