Electric Literature of 879668-17-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 879668-17-4, name is 4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine hydrochloride, molecular formula is C6H10ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 209.1 : To a suspension of 4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine hydrochloride (700mg) was added DIPEA (2.5ml) and Boc2O (0.945ml) at 0C. The reaction mixture was stirred at 0C for 2h, diluted with DCM and washed with water. The aq. phase was extracted with DCM. The combined org. layers were dried (MgSO4), filtered off and evaporated to dryness. The residue was purified by CC (Biotage, SNAP 25g cartridge, solvent A: DCM; solvent B: DCM/MeOH 8/2; gradient in %B: 15 for 3CV, 15 to 25 over 3CV, 25 for 5CV) to afford 1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester (298mg, white solid). LC-MS (B): tR = 0.50min; [M+H]+: 223.96.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 879668-17-4, 4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine hydrochloride.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; KELLER, Marcel; KIMMERLIN, Thierry; MEYER, Emmanuel; WO2013/114332; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem