Introduction of a new synthetic route about 677728-92-6

The synthetic route of 677728-92-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 677728-92-6, 2-Fluoropyridine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Fluoropyridine-5-carbaldehyde, blongs to pyridine-derivatives compound. Quality Control of 2-Fluoropyridine-5-carbaldehyde

A solution of 2-hydroxy-4-methoxy-aniline hydrochloride (20.2 mmol) and triethylamine (2.9 mL) in dry MeOH (150 mL) was treated with 2-fluoro-5-formylpyridine (2.477 g). The resulting mixture was stirred at rt for 40 mins and then concentrated to dryness to give 7.74 g of a reddish-orange solid. The residue was separated between CH2Cl2 (400 mL) and brine (200 mL) and the aqueous layer further extracted with (3 x 200 mL) CH2Cl2, the combined organics were then dried with Na2SO4, filtered and evaporated to give 5.36 g of an orange solid (quantitative yield): MS m/z 247 (M+H).The residue was taken up in dry CH2Cl2 (250 mL) and 2,3-dichloro-5,6-dicyano-l,4- benzoquinone (DDQ, 5.59 g) was added. After stirring at room temperature for 45 min, the resulting mixture was diluted with CH2Cl2 (500 mL), gravity filtered with a fluted filterpaper and the filtrate washed with saturated aqueous Na2CO3 (3 x 150 mL). The combined aqueous layers were back-extracted with (200 mL) CH2Cl2 and the combined organic layers washed with brine (200 mL). The organic layer was dried with Na2SO4 and evaporated to give 4.42 g of a brown solid. The crude was purified by flash column chromatography (SiO2, Heptane :EtO Ac 0-M00%) to give the title compound as a white solid 1.99 g (41% yield over two steps): IH NMR delta ppm 8.98 (d, 1 H) 8.61 – 8.69 (m, 1 H) 7.73 (d, 1 H) 7.41 – 7.49 (m, 2 H) 7.04 (dd, 1 H) 3.86 (s, 3 H); MS m/z 245 (M+H).

The synthetic route of 677728-92-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2007/149030; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem