Biosynthesis of guanitoxin enables global environmental detection in freshwater cyanobacteria was written by Lima, Stella T.;Fallon, Timothy R.;Cordoza, Jennifer L.;Chekan, Jonathan R.;Delbaje, Endrews;Hopiavuori, Austin R.;Alvarenga, Danillo O.;Wood, Steffaney M.;Luhavaya, Hanna;Baumgartner, Jackson T.;Dorr, Felipe A.;Etchegaray, Augusto;Pinto, Ernani;McKinnie, Shaun M. K.;Fiore, Marli F.;Moore, Bradley S.. And the article was included in Journal of the American Chemical Society in 2022.Formula: C8H10NO6P The following contents are mentioned in the article:
Harmful cyanobacterial blooms (cyanoHABs) cause recurrent toxic events in global watersheds. Although public health agencies monitor the causal toxins of most cyanoHABs and scientists in the field continue developing precise detection and prediction tools, the potent anticholinesterase neurotoxin, guanitoxin, is not presently environmentally monitored. This is largely due to its incompatibility with widely employed anal. methods and instability in the environment, despite guanitoxin being among the most lethal cyanotoxins. Here, we describe the guanitoxin biosynthesis gene cluster and its rigorously characterized nine-step metabolic pathway from
(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Formula: C8H10NO6P