Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 771579-27-2, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below., Quality Control of 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one
[01709] The above acid (0.47 g, 1 .52 mmol) was then dissolved in DMSO (5 mL) and 3- (amino methyl)-4, 6-dimethylpyridin-2( l H)-one (0.462 g, 3.04 mmol) was added.. The reaction mixture was stirred at room temperature for 15 min before PYBOP (1 .18 g, 2.28 mmol) was added to it and stirring was continued overnight. After completion of the reaction, reaction mass was poured into ice to obtain a solid which was filtered and dried to afford the title compound (0.40 g, 59%). LCMS: 444.25 (M + 1 )+; HPLC: 96.85% ((at) 254 nm) (R,;6.3 10; Method: Column: YMC ODS-A 150 mm x 4.6 mm x 5 mu; Mobile Phase: A; 0.05% TFA in water/ B; 0.05% TFA in acetonitrile; Jnj. Vol: 10 mu, Col. Temp.: 30 C; Flow rate: 1 .4 mL/min.; Gradient: 5% B to 95% B in 8 min, Hold for 1 .5 min, 9.5 1 – 12 min 5% B); NMR (DMSO-Patent; EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun; WO2012/142513; (2012); A1;,
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