Adding a certain compound to certain chemical reactions, such as: 183208-35-7, 5-Bromo-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 183208-35-7, blongs to pyridine-derivatives compound. Recommanded Product: 5-Bromo-1H-pyrrolo[2,3-b]pyridine
The 5-bromo-7-azaindole 27 (0.5 g, 2.54 mmol), bis (pinacolato) diboron (0. 968 g, 3. 81 mmol), potassium acetate (0.748 g, 7.61 MMOL), [1,1′- bis (diphenylphosphino) ferrocene] dichloropalladium (II) complex with CH2C12 (1: 1) (49 mg, 0.06 mmol) and DMF (11 ML) were heated in a sealed tube at 80 C. After 44 h, the reaction mixture was allowed to cool to room temperature, diluted with EtOAc and saturated brine, and partitioned. The aqueous layer was extracted with EtOAc (3X). The combined organic extracts were washed with brine (LX), dried (MgSO4), filtered and concentrated in vacuo. The crude pinacol ester 44 was used directly for the next step without any further PURIFICATION. 1H NMR (400 MHz; CDC13) 8 1. 38 (s, 12H), 6.51 (d, J= 3.5 Hz, 1H), 7.32 (d, J= 3.5 Hz, 1H), 8. 42 (d, J= 1.2 Hz, 1H), 8. 63 (d, J= 1.2 Hz, 1H) and 10.59 (brs, NH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,183208-35-7, its application will become more common.
Reference:
Patent; EISAI LONDON RESEARCH LABORATORIES LIMITED; WO2004/78757; (2004); A2;,
Pyridine – Wikipedia,
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