Synthesis of 2-hydroxy-5-(2′,3′,5′,6′-tetrafluoropyridylazo)benzaldehyde and 2-hydroxy-5-(2′,3′,5′,6′-tetrafluoro-pyridylazo)phenyl N-sulphanilamide-1-imine was written by Choula, Samira;Sekhri, Lakhdar;Hadjadj, Sadek. And the article was included in Heterocyclic Letters in 2020.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:
The present work aimed mainly to synthesize new fluorinated azo-compounds and Schiff base. Thus pentafluoropyridine was aminated to the compound 4-amino-2,3,5,6-tetrafluoropyridine and then diazotized to the corresponding diazonium compound The resulting diazonium ions coupled, in-situ, to salicylaldehyde giving the corresponding azo-compounds, i.e., 2-hydroxy-5-(2′,3′,5′,6′-tetrafluoropyridylazo)benzaldehyde and 2-hydroxy-3-(2′,3′,5′,6′-tetrafluoropyridylazo)benzaldehyde as red crystals in 85% yield. The purity of these azo-compounds were estimated by TLC technique while their structures were established by the usual spectroscopic methods such as A UV, IR, MS and 1H NMR. Fluorinated azo-compound coupled readily to salicylaldehyde resulting a new fluorinated base Schiff, 2-hydroxy-5-(2′,3′,5′,6′-tetrafluoro-pyridylazo)phenyl N-sulfanilamide-1-imine in 40% yield. The purity of this product was established by its IR, NMR and mass spectra. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of 2,3,4,5,6-Perfluoropyridine