Reactions of pentafluoropyridine with amidoximes was written by Ranjbar-Karimi, Reza;Karbakhsh-Ravari, Asma;Poorfreidoni, Alireza. And the article was included in Journal of the Iranian Chemical Society in 2017.Computed Properties of C5F5N The following contents are mentioned in the article:
In this paper, site reactivity of amidoximes with pentafluoropyridine under basic conditions in dry CH3CN was investigated. The aromatic nucleophilic substitution of pentafluoropyridine with amidoximes occurs in the 4-position of the pyridine ring by the oxygen site of amidoximes and followed by reaction of other sites, depending on reaction conditions. Substituted imidamide systems were readily accessed using a 1:1 molar ratio of pentafluoropyridine and amidoximes in concentrated acetonitrile and in reflux condition for 6 h, while reaction of pentafluoropyridine with amidoximes in 1:1 molar ratio and in diluted acetonitrile under reflux condition for 24 h gave novel pyridooxadiazine system. Pentafluoropyridine reacts also with amidoximes in 2:1 molar ratio under dry conditions to afford the bis-perfluoropyridyl imidamide systems. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Computed Properties of C5F5N).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C5F5N