Adding a certain compound to certain chemical reactions, such as: 101012-32-2, (2-Chloropyridin-3-yl)acetonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2-Chloropyridin-3-yl)acetonitrile, blongs to pyridine-derivatives compound. name: (2-Chloropyridin-3-yl)acetonitrile
To a solution of 2-(2-methylpyridin-3-yl)acetoni- trile (1.0 g, 6.6 mmol) and methyl acrylate (1.8 mE, 19.9 mmol) in THF (10 mE) at 0 C. was added potassiumtert-butoxide (8.6 mE, 8.6 mmol, 1 M in THF) and the resulting reaction mixture stirred at 25 C. for 3 h. The mixture was partitioned between H20 (100 mE) and EtOAc (80 mE), the aqueous layer further extracted with EtOAc (2×80 mE), combined organics dried (Na2SO4) and the solvent removed in vacuo. The residue was purified by colunm chromatography (normal silica, mesh size: 60-120, 0% to 0.5% MeOH in DCM) to give methyl 5-(2-chloro- pyridin-3-yl)-5-cyano-2-oxocyclohexane- 1 -carboxylate (1.2 g, 63%) as a yellow liquid.ECMS (Method F): mlz 293 (M+H) (ESj, at 1.97 mm UV active.
The synthetic route of 101012-32-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Heptares Therapeutics Limited; Brown, Giles Albert; Congreve, Miles Stuart; Pickworth, Mark; Tehan, Benjamin Gerald; (107 pag.)US2018/105491; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem