Catalytic Conversion of N-Heteroaromatics to Functionalized Arylamines by Merging Hydrogen Transfer and Selective Coupling was written by Tan, Zhenda;Ci, Chenggang;Yang, Jian;Wu, Yang;Cao, Liang;Jiang, Huanfeng;Zhang, Min. And the article was included in ACS Catalysis in 2020.Category: pyridine-derivatives The following contents are mentioned in the article:
A ruthenium-catalyzed deconstruction of N-heteroaromatics to functionalized arylamines with 2-aminoaryl methanols via hydrogen transfer and selective coupling was reported. The reaction was achieved via sequential functionalization of the 尾 and 伪-sites of the initially formed N-heteroarenium salts followed by a C-N cleavage, proceeding with the striking features of broad substrate scope, excellent functional groups tolerance, high chemoselectivity and atom-efficiency, and applicable for streamline synthesis of some biomedical mols. The strategy utilized will pave the avenues for further development of catalytic transformations of inert organo-systems to functional frameworks. This study involved multiple reactions and reactants, such as (3-Aminopyridin-2-yl)methanol (cas: 52378-63-9Category: pyridine-derivatives).
(3-Aminopyridin-2-yl)methanol (cas: 52378-63-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives