Photoredox Polyfluoroarylation of Alkyl Halides via Halogen-Atom-Transfer was written by Niu, Ben;Sachidanandan, Krishnakumar;Blackburn, Bryan G.;Cooke, Maria Victoria;Laulhe, Sebastien. And the article was included in Organic Letters in 2022.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:
The first polyfluoroarylation of unactivated alkyl halides RX (R = n-nonyl, cyclohexyl, adamantan-1-yl, 1-[(thiophen-2-yl)carbonyl]piperidin-4-yl, etc.; X = I, Br) e.g., I via halogen-atom-transfer process was described. This method converts primary, secondary, and tertiary alkyl halides into the resp. polyfluoroaryl compounds e.g., 3-(perfluorophenyl)butyl 4-methoxybenzoate in good yields in the presence of amide, carbamate, ester, aromatic and sulfonamide moieties including derivatives of complex bioactive mols. Mechanistic work revealed that this transformation proceeds through an alkyl radical generated after a halogen-atom-transfer. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 2,3,4,5,6-Perfluoropyridine