Ruthenium-Catalyzed Straightforward Synthesis of 1,2,3,4-Tetrahydronaphthyridines via Selective Transfer Hydrogenation of Pyridyl Ring with Alcohols was written by Xiong, Biao;Li, Ya;Lv, Wan;Tan, Zhenda;Jiang, Huanfeng;Zhang, Min. And the article was included in Organic Letters in 2015.Name: (3-Aminopyridin-2-yl)methanol The following contents are mentioned in the article:
Through a ruthenium-catalyzed selective hydrogen transfer coupling reaction, a novel straightforward synthesis of 1,2,3,4-tetrahydronaphthyridines e. g., I, from o-aminopyridyl methanols and alcs. has been developed. The synthetic protocol proceeds in an atom- and step-economic fashion together with the advantages of operational simplicity, broad substrate scope, production of water as the only byproduct, and no need for external reducing reagents such as high pressure H2 gas, offering a highly practical approach for accessing this type of structurally unique products. This study involved multiple reactions and reactants, such as (3-Aminopyridin-2-yl)methanol (cas: 52378-63-9Name: (3-Aminopyridin-2-yl)methanol).
(3-Aminopyridin-2-yl)methanol (cas: 52378-63-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Name: (3-Aminopyridin-2-yl)methanol