Electric Literature of 14254-57-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 14254-57-0 as follows.
Compound 1 (455 mg, 0.64 mmol) was dissolved in 10 mL of dry dichloromethane,Additional triethylamine (130 mg, 1.28 mmol) was added. Compound 2 (272 mg, 1.92 mmol) was added portionwise to the reaction under ice-water bath conditions. The reaction liquid nitrogen protection, 0 C for half an hour, then at room temperature for 5 hours, TLC detection reaction was complete. To the reaction mixture was added 150 mL of methylene chloride, and the organic phase was washed with saturated brine (150 mL ¡Á 3) and dried over anhydrous sodium sulfate. Suction filtration and distillation under reduced pressure to give the crude product, which was purified by column chromatography with methylene chloride / methanol = 20/1 to obtain 425 mg of the pure product of Intermediate 3 as a yellow solid in a yield of 81.4%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14254-57-0, its application will become more common.
Reference:
Patent; Shandong University; Zhao Baoxiang; Miao Junying; Zhang Xiaofan; Zhao Xuan; (10 pag.)CN106632363; (2017); A;,
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