Nucleophilic aromatic substitution of polyfluoroarenes to access highly functionalized 10-phenylphenothiazine derivatives was written by Kikushima, Kotaro;Koyama, Haruka;Kodama, Kazuki;Dohi, Toshifumi. And the article was included in Molecules in 2021.Synthetic Route of C5F5N The following contents are mentioned in the article:
Nucleophilic aromatic substitution (SNAr) reactions can provide metal-free access to synthesize monosubstituted aromatic compounds An efficient SNAr conditions for para-selective substitution of polyfluoroarenes with phenothiazine in the presence of a mild base to afford the corresponding 10-arylphenothiazine derivatives have been developed. The resulting polyfluoroarene-bearing phenothiazines were subjected to a second SNAr reaction to generate highly functionalized derivatives with potential applicability as photocatalysts for the reduction of carbon-halogen bonds. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule ä¼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C5F5N