2,2,2-Trifluoroethanol as a solvent to control nucleophilic peptide arylation was written by Gimenez, Diana;Dose, Anica;Robson, Nicholas L.;Sandford, Graham;Cobb, Steven L.;Coxon, Christopher R.. And the article was included in Organic & Biomolecular Chemistry in 2017.Name: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:
The SNAr arylation of peptides with perfluoroaroms. provides a route by which to install a useful chem. handle that enables both 19F-NMR anal. and further chem. modification. However, chemo-selective arylation in peptides containing multiple nucleophilic side chains currently presents a challenge to the field. Herein, we demonstrate that employing 2,2,2-trifluoroethanol (TFE) as a solvent in peptide SNAr reactions significantly improves nucleophile-selectivity when compared to N,N’-dimethylformamide (DMF). This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Name: 2,3,4,5,6-Perfluoropyridine).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: 2,3,4,5,6-Perfluoropyridine