Organocatalytic Arylation of ä¼?Ketoesters Based on Umpolung Strategy: Phosphazene-Catalyzed SNAr Reaction Utilizing [1,2]-Phospha-Brook Rearrangement was written by Kondoh, Azusa;Aoki, Takuma;Terada, Masahiro. And the article was included in Chemistry – A European Journal in 2018.Reference of 700-16-3 The following contents are mentioned in the article:
An organocatalytic arylation of ä¼?ketoesters was developed on the basis of umpolung strategy. Phosphazene P2-tBu efficiently catalyzes the three-component coupling reaction of ä¼?ketoesters, a silylated secondary phosphite, and electron-deficient fluoroarenes to provide ä¼?hydroxyester derivatives possessing an electron-deficient aryl group at the ä¼?position. The reaction involves the catalytic generation of ä¼?oxygenated ester enolates from ä¼?ketoesters through the [1,2]-phospha-Brook rearrangement followed by the SNAr reaction. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Reference of 700-16-3).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 700-16-3