Survey Reactivity of Some Substituted Quinazolinones with Pentafluoro(chloro)pyridine was written by Ranjbar-Karimi, Reza;Davodian, Tayebeh;Mehrabi, Hossein. And the article was included in Journal of Heterocyclic Chemistry in 2018.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:
A new series of 4-hetroaryl substituted quinazolines, e.g. I, were designed and synthesized by the reaction of pentafluoro(chloro)pyridine and 2-substituted quinazolinone. The aromatic nucleophilic substitution of pentafluoro(chloro)pyridine with quinazolinone occurs at the 4-position of pyridine ring by the oxygen site (O-centered nucleophile) of quinazolinone. The structures of all the compounds were confirmed by IR, 1H NMR, 19F NMR, and 13C NMR spectroscopy as well as elemental anal. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application In Synthesis of 2,3,4,5,6-Perfluoropyridine).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJè·¯molé? in pyridine vs. 150 kJè·¯molé? in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 2,3,4,5,6-Perfluoropyridine