Extracurricular laboratory: Synthetic route of 2-Methoxypyridin-3-amine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20265-38-7, 2-Methoxypyridin-3-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 20265-38-7, 2-Methoxypyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H8N2O, blongs to pyridine-derivatives compound. Formula: C6H8N2O

26.5 g (58.6 mmol) of compound IV was dissolved in 79 ml of 1,4-dioxane.To this solution was added 11.35 g (87.90 mmol)8.724 g (70.32 mmol) of diisopropylethylamine and 2-methoxy-3-aminopyridine.After refluxing for 18 hours, the residual 1,4-dioxane was removed under reduced pressure.The residual solid was dispersed in 57 ml of 95percent ethanol and stirred by suction.The filter cake was washed with 114 ml of absolute ethanol and dried.Get a yellow solid27.6g,The yield was 84.7percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20265-38-7, 2-Methoxypyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; Beijing Concorde Pharmaceutical Er Factory; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Zhang Dongfeng; Huang Haihong; Li Chun; Yin Dali; Lin Ziyun; Ma Chen; Wang Mijuan; Zhang Meng; Lan Pei; Zhao Limin; (11 pag.)CN109748903; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem