SNAr catalysis enhanced by an aromatic donor-acceptor interaction; facile access to chlorinated polyfluoroarenes was written by Senaweera, Sameera;Weaver, Jimmie D.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Reference of 700-16-3 The following contents are mentioned in the article:
Selective catalytic SNAr reaction of polyfluoroaryl C-F bonds with chloride is shown. Stoichiometric TMSCl makes the reaction exergonic and allows catalysis, which involves ground state elevation of chloride, aromatic donor-acceptor interactions, and stabilization of the Meisenheimer complex. Traditional cross-coupling of the products is now possible and demonstrates the utility. Thus, e.g., treatment of pentafluoropyridine with TMSCl and benzyltributylammonium chloride afforded 4-chloro-2,3,5,6-tetrafluoropyridine (95%). This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Reference of 700-16-3).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of é?8.7 è?10é? cm3è·¯molé?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJè·¯molé? in the liquid phase and 140.4 kJè·¯molé? in the gas phase. Pyridine derivatives are also useful as small-molecule ä¼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 700-16-3