The synthetic strategy of new pyridine clubbed acetamides via N-alkylation/C-N coupling reaction, sulfonamide drug and their biological approach was written by Yogi, Prabhunath;Prajapat, Prakash;Hussain, Nassir;Dhawan, Heena;Joshi, Ajit. And the article was included in Heterocyclic Letters in 2017.COA of Formula: C12H11BrN2O2S The following contents are mentioned in the article:
A library of novel pyridine motifs assembled with isatin/thiazolidione/sulfonamide/pyrazolone were designed and synthesized via N-alkylation (C-N coupling) approach. The target compounds were obtained by a two step synthetic strategy starting from substituted 2-aminopyridine using appropriate synthetic routes. The synthesized compounds were tested for their in vitro antimicrobial and in vivo anti-inflammatory activity. Some of the compounds were found to be more active than the reference drugs. This study involved multiple reactions and reactants, such as N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3COA of Formula: C12H11BrN2O2S).
N-(5-Bromopyridin-2-yl)-4-methylbenzenesulfonamide (cas: 207801-52-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the è?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the è?bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one Cé¥æ in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.COA of Formula: C12H11BrN2O2S