Highly Selective Pd-Catalyzed Direct C-F Bond Arylation of Polyfluoroarenes was written by Luo, Zhi-Ji;Zhao, Hai-Yang;Zhang, Xingang. And the article was included in Organic Letters in 2018.Name: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:
A directing-group-free palladium-catalyzed direct arylation of simple polyfluoroarenes with arylboronic acids through selective C-F bond activation is described. The combination of Pd(OAc)2 with BrettPhos was identified as an efficient catalytic system to promote the reaction with high regioselectivity and broad substrate scope. Preliminary mechanistic studies reveal that the oxidative addition of Pd to the C-F bond is involved in the catalytic cycle. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Name: 2,3,4,5,6-Perfluoropyridine).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the è?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the è?bonds. Pyridine derivatives are also useful as small-molecule ä¼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Name: 2,3,4,5,6-Perfluoropyridine