Electric Literature of 2459-07-6 , The common heterocyclic compound, 2459-07-6, name is Methyl picolinate, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A suspension of methyl picolinate (6 g, 0.043 mol, 1 equiv) and hydrazine hydrate (4.3 g, 0.08 mol, 2.0 equiv) in EtOH (50 ml) was stirred at 90C for ovemignt. Product formation was confirmed by TLC and LCMS. The resulting mixture was concentrated under reduced pressure, the residue was dissolved in ethyl acetate and distilled water. Organic phase was separated, dried over anhydrous Na2S04 and it was concentrated under reduced pressure to give crude. The crude product was washed with diethyl ether to obtain picolinohydrazide (5.2 gm, as off white solid). ‘H NMR (400MHz, DMSO-ri6) d = 9.87 (br. s., 1H), 8.61 (d,.7= 4.8 Hz, 1H), 8.03 – 7.90 (m, 2 H), 7.57 (dt, J = 3.3, 5.2 Hz, 1H), 4.62 (br. s., 2 H).
The synthetic route of 2459-07-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRAXIS BIOTECH LLC; ALFARO, Jennifer; BELMAR, Sebastian; NUNEZ VASQUEZ, Gonzalo Esteban; PUJALA, Brahmam; SATHE, Balaji Dashrath; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; THAKRAL, Pooja; PATIDAR, Rajesh Kumar; (344 pag.)WO2019/195810; (2019); A2;,
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