Sun, Chi-Yu published the artcileSynthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives, Recommanded Product: 4-(5-Nitropyridin-2-yl)morpholine, the main research area is phenoxybenzamide cycloaliphatic amine preparation human antiproliferative hedgehog signaling inhibitor.
A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety I (R1 = Me, OCF3, OMe, Cl; X = O, CH2), II (R2 = Ph, 3-MeOC6H4, 2-pyridyl, 3,4-Cl2C6H3, etc.) were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacol. data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound I (R1 = OCF3; X = O) showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of I (R1 = OCF3; X = O) showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization.
Chinese Chemical Letters published new progress about Antitumor agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Recommanded Product: 4-(5-Nitropyridin-2-yl)morpholine.