Walsh, Katie published the artcileAmination of Heteroaryl Chlorides: Palladium Catalysis or SNAr in Green Solvents?, Product Details of C9H11N3O3, the main research area is pyrimidine pyrazine quinazoline preparation; heteroaryl chloride amine SNAr arylation water potassium fluoride; amination; aromatic substitution; green chemistry; nucleophilic substitution.
The reaction of heteroaryl chlorides in the pyrimidine, pyrazine and quinazoline series with amines in water in the presence of KF results in a facile SNAr reaction and N-arylation products, e. g., I. The reaction is less satisfactory with pyridines unless an addnl. electron-withdrawing group is present. The results showed that the transition-metal-free SNAr reaction not only compares favorably to palladium-catalyzed coupling reactions but also operates under environmentally acceptable (“”green””) conditions in terms of the base and solvent.
ChemSusChem published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Product Details of C9H11N3O3.