Zimmermann, Viktor published the artcileChemoselective reduction of nitroarenes in the presence of acid-sensitive functional groups: Solid-phase syntheses of amino aryl azides and benzotriazoles, Application In Synthesis of 36437-30-6, the main research area is chemoselective reduction nitroarene acid sensitive functional group present; solid phase synthesis amino aryl azide benzotriazole.
The authors demonstrated the 1st chemoselective reduction of nitroarenes on solid supports in the presence of other reducible functional groups such as triazenes. A unique combination of a single-electron transfer reagent (viologen) with Na2S proved to be convenient in terms of reducing the strength and for the workup. The relatively long reaction times appear justified, considering the possibilities for further diversification of yielded aminoarenes on solid supports. From o-nitroanilines, for example, >95% 5-methyl-1H-benzotriazole was obtained from 5-methyl-2-nitroaniline via formation of the diazonium tetrafluoroborate, reaction with [(benzylamino)methyl]-modified polystyrene (from Merrifield resin) to give a supported triazene, selective reduction using Na2S/K2CO3/1,1′-dioctyl-4,4′-bipyridinium(2+) dibromide, and cleavage of the resin using 5% trifluoroacetic acid in the presence of TMSN3. Azidoanilines were formed by the above sequence from 4-nitroaniline and Me 5-amino-2-nitrobenzoate.
Journal of Combinatorial Chemistry published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation) (azido). 36437-30-6 belongs to class pyridine-derivatives, name is 1,1-Di-n-octyl-4,4-bipyridinium Dibromide, and the molecular formula is C26H42Br2N2, Application In Synthesis of 36437-30-6.