Gulevskaya, Anna V. published the artcileC-N bond formation by the oxidative alkylamination of azines: comparison of AgPy2MnO4 versus KMnO4 as oxidant, Formula: C9H11N3O3, the main research area is pyridine quinazoline amine oxidative alkylamination permanganate; aminopyridine preparation; aminoquinazoline preparation; permanganate oxidative alkylamination oxidant.
Reports on the successful oxidative alkylamination of azines by the SN-reaction, with the use of alkylamines other than methylamine, are very scarce. Hitherto, the exptl. limitation to extend oxidative amination of azines with NH3/KMnO4 to oxidative alkylamination is solely ascribed to the low solubility of KMnO4 in alkylamines and the increased sensitivity of alkylamines towards oxidation in comparison with ammonia. The exptl. data proved that there is also a substrate dependence in this type of reaction. 2-Alkylamino-5-nitropyridines and 4-alkylaminoquinazolines were smoothly obtained by the treatment of 3-nitropyridine and quinazoline, resp., with alkylamine/AgPy2MnO4. Although KMnO4 still gives moderate to good results with 3-nitropyridine, it is completely useless for reactions with quinazoline with the same alkylamines. The use of AgPy2MnO4 was found to give equal or superior results to those of KMnO4 depending on the alkylamine and the substrate used and therefore seems to be a promising general oxidant for successful oxidative alkylaminations.
European Journal of Organic Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Formula: C9H11N3O3.