Khattab, Sherine N. published the artcileAminolysis of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine, Application of 4-(5-Nitropyridin-2-yl)morpholine, the main research area is hydroxybenzotriazole aminolysis reaction mechanism kinetics solvent effect.
The reaction 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with amines undergoes amination followed by elimination of the 1-hydroxyl benzotriazolyl anion. The kinetic data for the reaction of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with morpholine (Mo), cyclohexylamine (CHA) and aniline (An) in MeOH and acetonitrile (AN) proceeded by uncatalyzed mechanism in which the rate limiting step is the leaving group departure, whereas the reaction with Mo in toluene proceeded by uncatalyzed mechanism in which the formation of the zwitterionic intermediate is the rate determining step. While the reactions of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene with CHA and An and the reaction of 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with CHA in toluene proceeded by the specific base (SB) mechanism in which the rate determining step is the proton transfer process. The reactions of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with Mo in the three solvents and with CHA and An in MeOH and AN is greatly dependent on the stability of the zwitterionic intermediate. The effect of ring activation is due to the ground state stabilization and the more efficient delocalization of the neg. charge with a nitro group than with a ring-nitrogen in the transition state. The low activation enthalpies ΔH# and the highly neg. activation entropies ΔS# are due to the intramol. hydrogen bonding with the ammonio hydrogen present in the transition state.
Open Journal of Physical Chemistry published new progress about Activation enthalpy. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Application of 4-(5-Nitropyridin-2-yl)morpholine.