Khattab, Sherine N. published the artcileSynthesis and aminolysis of 2,4-dinitrophenyl and 5-nitropyridine N-hydroxy oxime derivatives, Application In Synthesis of 26820-62-2, the main research area is aminolysis dinitrophenyl nitropyridine oxime morpholine nucleophilic aromatic substitution kinetics.
The 2,4-dinitrophenoxy derivatives 12-16 and the 5-nitro-2-pyridyloxy derivatives 18-22 were prepared The products were identified by elemental anal., IR, and NMR. The reaction of 12-16 and 18-22 with morpholine as nucleophile in CH3CN occurs through nucleophilic aromatic substitutions to give N-(2,4-dinitrophenyl)morpholine (23) and N-(5-nitro-2-pyridyl)morpholine (24) resp. Spectrophotometric measurements of the kinetics of these reactions in CH3CN at a range of temperatures indicated that they are not morpholine-catalyzed. The Bronsted-type plots for the reactions of 12-16 and 18-22 with morpholine are linear with slopes, β12-16 = -1.58 ± 0.1 and β18-22 = -1.15 ± 0.25 resp. The relative rate constants compared to the least reactive substrate, as well as the low neg. β values, supported that the decomposition of the zwitterionic intermediate is a slow process. The low activation parameters (ΔH# and ΔS#) are in accordance with the proposed transition state (T#). The expulsion of RO- anion in the rate-determining step is assisted by intramol. hydrogen-bonding with the ammonio-hydrogen present in the intermediate T#.
Bulletin of the Chemical Society of Japan published new progress about Activation enthalpy. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Application In Synthesis of 26820-62-2.