Suzuki, Hiroyuki published the artcileAcute kidney injury successfully treated with autologous granulocyte colony-stimulating factor-mobilized peripheral blood CD34 -positive cell transplantation: A first-in-human report, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is autologous GCSF peripheral blood cell transplantation acute kidney injury; CD34+; clinical trials; granulocyte-colony stimulating factor (G-CSF); hematopoietic stem cells (HSCs); kidney; stem cell transplantation.
A 36-yr-old man with severe acute kidney injury (AKI) was admitted to Shonan Kamakura General Hospital in Japan. He was diagnosed with refractory hypertension based on a severely elevated blood pressure of 224/116 mmHg and retinal, cardiac, and brain damage revealed by ECG, fundoscopy, and magnetic resonance imaging, resp. Although hemodialysis was withdrawn following strict blood pressure control by an angiotensin receptor blocker, severe kidney insufficiency persisted. Therefore, we performed an autologous granulocyte colonystimulating factor-mobilized peripheral blood CD34-pos. cell transplantation. Collected CD34-pos. cells were directly infused to both renal arteries. The patient’s general condition was unremarkable after intervention, and the serum creatinine level gradually improved to 2.96 mg/dL 23 wk after cell therapy. Although transient fever and thrombocytosis were observed after intervention, no major adverse events were observed This patient is the first case in a phase I/II clin. trial of autologous granulocyte colony-stimulating factor-mobilized peripheral blood CD34-pos. cell transplantation for severe AKI with a CD34-pos. cell doseescalating protocol (trial number jRCTb030190231).
Stem Cells Translational Medicine published new progress about Acute kidney injury. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.