Patel, Nehanshu published the artcileComparative evaluation of different marketed brands of itraconazole, Formula: C18H19Cl2NO4, the main research area is itraconazole dissolution economic pharmaceutical analysis.
Efficacy of pharmaceutical dosage form generally depends on their formulation and manufacturing methods, hence it is likely that the quality of dosage form may vary. The free azole nitrogen competes for oxygen at the catalytic heme of cytochrome P 450 enzyme. Inhibition of cytochrome P 450 enzyme prevents the synthesis of ergosterolin fungal cell membranes by limiting the C14 demethylation of lanosterol, which is criticalfor the synthesis of ergosterol. The study was exclusively exptl. that used IP and otherstandard books to check in vitro quality of Itraconazole tablet using different anal. techniques and procedure. Test for weight variation, hardness, friability, disintegration time and dissolution were conducted. The dissolution test was performed at pH 6.8 for both brandsof the tablet. Further all the tablet passed weight variation, hardness, and friability and disintegration test as per the pharmacopoeial standard Hence we can conclude that both the brands of tablets are equal quantity of active pharmaceutical ingredient (API). Both the brands having higher and lower costs exert similar action.
World Journal of Pharmacy and Pharmaceutical Sciences published new progress about Cardiac arrhythmia. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Formula: C18H19Cl2NO4.