Cui, Haiming published the artcileThe effects of renin-angiotensin system inhibitors (RASI) in coronavirus disease (COVID-19) with hypertension: A retrospective, single-center trial, Safety of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is human covid19 renin angiotensin system inhibitor; Coronavirus disease 2019; Enfermedad Coronavirus 2019; Hipertensión; Hypertension; Renin-inhibidores del sistema de angiotensina; Renin–angiotensin system inhibitors.
A recent outbreak of coronavirus disease 2019 (COVID-19) occurs in the worldwide. Angiotensin-converting enzyme 2 (ACE2) can mediate coronavirus entry into host cells. Therefore, renin-angiotensin system inhibitors (RASI) were suspected of contributing to the increase of coronavirus infection. We aimed to analyze the effects of RASI in COVID-19 patients with hypertension.In this retrospective, single-center study, 27 COVID-19 patients with hypertension, who were admitted to the Shanghai Public Health Clin. Center from Jan. 25, 2020 to Jan. 31, 2020, were analyzed for clin. features, laboratory parameters, medications and the length of stay. All the patients were given antiviral and antihypertension treatment, of which 14 patients were treated with RASI and 13 patients without RASI. Comparing the two groups, we did not found statistically significant differences in clin. symptoms and laboratory tests. Furthermore, cough was not aggravated. Through the anal. of this small sample, RASI could be deemed safe and effective to control high blood pressure of COVID-19 patients. Further anal. with a larger sampling size is required to explore the underlying mechanisms.
Medicina Clinica published new progress about Antihypertensives. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Safety of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.