Adding a certain compound to certain chemical reactions, such as: 942947-94-6, 5-Bromo-4-chloropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H4BrClN2, blongs to pyridine-derivatives compound. Computed Properties of C5H4BrClN2
A mixture of water (2.2 mL) and concentrated sulfuric acid (0.31 mL, 5.78 mmol) was cooled to 0 C and 5-bromo-4-chloropyridin-2-amine (500 mg, 2.41 mmol) was added in one portion. A solution of sodium nitrite (183 mg, 2.65 mmol) in water (0.2 mL) was added dropwise so that the internal temperature did not rise above 5 C. The reaction was stirred at 0 C for 3 h. The suspension was taken to pH 7 by addition of (0687) concentrated aqueous ammonia and the precipitate was collected by filtration to give the title compound (440 mg, 88%) as a pale yellow solid. LCMS (Method B): RT = 0.70 min, m/z = 209 [M+H]+. 1 H NMR (400 MHz, DMSO-d6): delta 7.94 (s, 1 H), 6.75 (s, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,942947-94-6, 5-Bromo-4-chloropyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; ALMAC DISCOVERY LIMITED; HEWITT, Peter; MCFARLAND, Mary Melissa; ROUNTREE, James Samuel Shane; BURKAMP, Frank; BELL, Christina; PROCTOR, Lauren; HELM, Matthew Duncan; O’DOWD, Colin; HARRISON, Timothy; (280 pag.)WO2018/20242; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem